Natural Pro-oxidants: an Alternative Remedy to Explore as Novel Cancer Therapeutic Agents

Polyalthia longifolia Sonn: an Ancient Remedy to Explore for Novel Therapeutic Agents

Polyalthia longifolia (Sonn.) Thwaites (PL) (Family: Annonaceae) is a tall handsome evergreen tree and it is cultivated all over India. The plant has been commonly used in traditional system of medicine for the treatment of fever, skin diseases, diabetes, hypertension and helminthiasis. In view of the immense medicinal importance of P. longifolia, this review was aimed at compiling all currentl...

Cardiac glycosides as novel cancer therapeutic agents.

The class of steroid-like compounds designated cardiac glycosides includes well-known drugs such as digoxin, digitoxin, and ouabain. Their continued efficacy in treatment of congestive heart failure and as anti-arrhythmic agents is well appreciated. Less well known, however, is the emerging role of this category of compounds in the prevention and/or treatment of proliferative diseases such as c...

Therapeutic Significance of Natural Anti Oxidants

Implication for health policy/practice/research/medical education: This study helps to improve the research and practice. Copyright © 2013, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences; Licensee DocS Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unres...

therapeutic significance of natural anti oxidants

ATP citrate lyase inhibitors as novel cancer therapeutic agents.

ATP citrate lyase (ACL or ACLY) is an extra-mitochondrial enzyme widely distributed in various human and animal tissues. ACL links glucose and lipid metabolism by catalyzing the formation of acetyl-CoA and oxaloacetate from citrate produced by glycolysis in the presence of ATP and CoA. ACL is aberrantly expressed in many immortalized cells and tumors, such as breast, liver, colon, lung and pros...